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Efficacy and safety analysis of bevacizumab combined with capecitabine in the maintenance treatment of RAS‐mutant metastatic colorectal cancer

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The optimal strategy for maintenance therapy in patients with metastatic colorectal cancer (mCRC) remains controversial. Considering that, beyond progression, co‐therapy with bevacizumab and cytotoxic chemotherapy showed less toxicity and a… Click to show full abstract

The optimal strategy for maintenance therapy in patients with metastatic colorectal cancer (mCRC) remains controversial. Considering that, beyond progression, co‐therapy with bevacizumab and cytotoxic chemotherapy showed less toxicity and a significant disease control rate. We aimed to investigate the differences in efficacy and safety between bevacizumab combined with capecitabine maintenance therapy and capecitabine monotherapy for RAS‐mutant mCRC (as defined by mutations in KRAS and NRAS exons 2–4)controlled by bevacizumab plus FOLFIRI chemotherapy for at least 12 weeks.

Keywords: bevacizumab combined; maintenance; metastatic colorectal; bevacizumab; colorectal cancer; efficacy safety

Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2022

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