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Interaction between the HIF‐1α gene rs1957757 polymorphism and CpG island methylation in the promoter region is associated with the risk of anti‐tuberculosis drug‐induced liver injury in humans: A case–control study

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HIF‐1α gene polymorphisms, including rs11549465, rs11549467, rs1957757 and rs10873142, cause liver cell damage or pulmonary disease. The aim of this study was to analyse the association between the polymorphisms of… Click to show full abstract

HIF‐1α gene polymorphisms, including rs11549465, rs11549467, rs1957757 and rs10873142, cause liver cell damage or pulmonary disease. The aim of this study was to analyse the association between the polymorphisms of the loci of the HIF‐1α gene and its CpG island methylation in the promoter region with the risk of anti‐tuberculosis drug‐induced liver injury (ADLI).

Keywords: hif gene; cpg island; island methylation; methylation promoter; promoter region; gene

Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2022

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