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Timely and appropriate dosing of antibiotics is essential for the treatment of bacterial sepsis. Critically ill patients treated with continuous kidney replacement therapy (CKRT) often have physiologic derangements that affect… Click to show full abstract
Timely and appropriate dosing of antibiotics is essential for the treatment of bacterial sepsis. Critically ill patients treated with continuous kidney replacement therapy (CKRT) often have physiologic derangements that affect pharmacokinetics (PK) of antibiotics and dosing may be challenging. We sought to aggregate previously published piperacillin and tazobactam (pip‐tazo) pharmacokinetic data in critically ill patients undergoing CKRT to better understand pharmacokinetics of pip‐tazo in this population and better inform dosing.
Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2022
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