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ABCB1 gene polymorphisms impact the effect of high‐dose intravenous methylprednisolone therapy on optic neuritis associated with AQP4‐IgG‐positive neuromyelitis optica spectrum disorder

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Patients with optic neuritis (ON) have significant individual differences in their response to high‐dose intravenous methylprednisolone (HIMP) therapy. This study aims to evaluate the association between gene polymorphisms and the… Click to show full abstract

Patients with optic neuritis (ON) have significant individual differences in their response to high‐dose intravenous methylprednisolone (HIMP) therapy. This study aims to evaluate the association between gene polymorphisms and the efficacy of HIMP therapy in Chinese Han patients with ON mediated by aquaporin‐4 immunoglobulin G antibody (AQP4‐IgG) ‐positive neuromyelitis optica spectrum disorder (NMOSD) or multiple sclerosis (MS).

Keywords: therapy; gene polymorphisms; optic neuritis; dose intravenous; intravenous methylprednisolone; high dose

Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2022

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