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Metformin treatment decreases thyrotropin levels in individuals with hypothyroidism and this effect seems to be mediated by the 5′‐adenosine monophosphate‐activated protein kinase pathway in the pituitary. The activity of this… Click to show full abstract
Metformin treatment decreases thyrotropin levels in individuals with hypothyroidism and this effect seems to be mediated by the 5′‐adenosine monophosphate‐activated protein kinase pathway in the pituitary. The activity of this pathway is also stimulated by statins. The current study was aimed at investigating whether the impact of metformin on hypothalamic–pituitary–thyroid axis activity is affected by statin use.
Keywords:
effect;
thyrotropin lowering;
rosuvastatin potentiates;
lowering effect;
hypothyroidism;
potentiates thyrotropin
Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2022
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Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!