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Current vancomycin monitoring guidelines recommend the use of area under the concentration‐time curve (AUC24) monitoring in patients with serious Methicillin‐Resistant Staphylococcus aureus (MRSA) infections by utilizing either a Bayesian approach… Click to show full abstract
Current vancomycin monitoring guidelines recommend the use of area under the concentration‐time curve (AUC24) monitoring in patients with serious Methicillin‐Resistant Staphylococcus aureus (MRSA) infections by utilizing either a Bayesian approach or first‐order analytic equations. Several open‐access websites exist that allow estimation of vancomycin AUC24 with the use of a single steady‐state concentration. It is uncertain how these open‐access calculators perform against guideline‐recommended methods. The objective was to compare AUC24 estimates from two online, open‐access, single‐concentration vancomycin calculators compared with the two‐point pharmacokinetic (2PK) method.
Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2022
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