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Dosage optimization of voriconazole in children with haematological malignancies based on population pharmacokinetics

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Voriconazole has a complex pharmacokinetic profile and exhibits different pharmacokinetic characteristics in adults and children. Nevertheless, few studies have been conducted on the population pharmacokinetics (PPK) of voriconazole in children… Click to show full abstract

Voriconazole has a complex pharmacokinetic profile and exhibits different pharmacokinetic characteristics in adults and children. Nevertheless, few studies have been conducted on the population pharmacokinetics (PPK) of voriconazole in children with haematological malignancies. This study aims to build a PPK model and propose a suitable voriconazole treatment scheme for children with haematological malignancies.

Keywords: haematological malignancies; voriconazole children; population pharmacokinetics; children haematological

Journal Title: Journal of Clinical Pharmacy and Therapeutics
Year Published: 2022

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