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β‐Cell senescence in the pathogenesis of type 2 diabetes

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The prevalence of type 2 diabetes increases with aging, and the type 2 diabetes developing in the elderly is often accompanied by a gradual impairment of β‐cell function and reduced… Click to show full abstract

The prevalence of type 2 diabetes increases with aging, and the type 2 diabetes developing in the elderly is often accompanied by a gradual impairment of β‐cell function and reduced β‐cell mass along with aging. However, the contribution of β‐cell senescence to the pathogenesis of type 2 diabetes remains uncertain. In a recent Cell Metabolism article, Aguayo‐Mazzucato et al. described their efforts to identify the signatures of senescent β‐cells, and explored the role(s) of senescent β‐cells in type 2 diabetes.

Keywords: cell senescence; pathogenesis type; senescence pathogenesis; type diabetes; type

Journal Title: Journal of Diabetes Investigation
Year Published: 2019

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