LAUSR

We present the case of a 12-year-old Japanese girl, who was positive for markers of both, maturity onset diabetes of the young (MODY) and latent autoimmune diabetes in youth (LADY). She was initially diagnosed with MODY1 based on the molecular analysis, and she later developed an autoimmune response, leading to β-cell associated antibody positive diabetes. She was treated with incretin-associated drugs and maintained adequate glycemic control. Pathophysiologically, there was an overlap between the two different types of diabetes because the hyperglycemia and β-cell stress seen in non-autoimmune diabetes can cause β-cell autoimmunity over time.