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Kruppel‐like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes

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Brown adipose tissue (BAT) utilizes large amounts of fuel for thermogenesis, but the mechanism by which fuel substrates are switched in response to changes in energy status is poorly understood.… Click to show full abstract

Brown adipose tissue (BAT) utilizes large amounts of fuel for thermogenesis, but the mechanism by which fuel substrates are switched in response to changes in energy status is poorly understood. We have now investigated the role of Kruppel‐like factor 15 (KLF15), a transcription factor expressed at a high level in adipose tissue, in the regulation of fuel utilization in BAT.

Keywords: kruppel like; like factor; regulates fuel; factor regulates; fuel switching; factor

Journal Title: Journal of Diabetes Investigation
Year Published: 2021

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