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Islet β‐cells physiological difference study of old and young mice based on single‐cell transcriptomics

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Body aging is a universal biological process. With aging, cells undergo a series of physiological changes. The main feature is cell proliferation decline, although the cells still have normal functions.… Click to show full abstract

Body aging is a universal biological process. With aging, cells undergo a series of physiological changes. The main feature is cell proliferation decline, although the cells still have normal functions. Pancreatic β‐cells are no exception. However, the physiological senescence of β‐cells, and the resulting function and transcriptome changes have rarely attracted attention. The specific senescence phenotype of β‐cells remains unknown.

Keywords: physiological difference; cells physiological; difference study; islet cells; cell; study old

Journal Title: Journal of Diabetes Investigation
Year Published: 2021

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