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Type 2 diabetes is a systemic disorder characterized by metabolic impairment in multiple organs1 . Various factors trigger insulin resistance in muscle, liver and adipose tissue resulting in increased insulin… Click to show full abstract
Type 2 diabetes is a systemic disorder characterized by metabolic impairment in multiple organs1 . Various factors trigger insulin resistance in muscle, liver and adipose tissue resulting in increased insulin demand and de-repression of hepatic gluconeogenesis. When pancreatic β cells fail to compensate their mass and function to the increased insulin demand, β cell apoptosis and dedifferentiation occurs which leads to hyperglycemia.
Keywords:
mediators diabetes;
diabetes pathogenesis;
new mediators;
exosomes metabolites;
pathogenesis exosomes
Journal Title: Journal of diabetes investigation
Year Published: 2021
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Journal Title: Journal of diabetes investigation
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!