LAUSR

AIM There are mixed opinions on the influence of diabetes on the prognosis of patients receiving percutaneous coronary intervention (PCI). Therefore, in this study, the quantitative flow ratio (QFR), an emerging technology of functional evaluation, was used to explore the impact of diabetes on coronary physiology in patients who underwent PCI. MATERIALS AND METHODS Patients who underwent successful PCI and a one-year angiographic follow-up were retrospectively screened and analyzed by the QFR. Based on the presence or absence of diabetes, 677 enrolled patients (794 vessels) were classified into a diabetic group (211 patients, 261 vessels) and a nondiabetic group (466 patients, 533 vessels). The results of QFR analysis and clinical outcomes were compared between the two groups. RESULTS The two groups reached a similar level of post-PCI QFR (0.95 ± 0.09 vs. 0.96 ± 0.06, p = 0.292). However, at the one-year follow-up, the QFR was lower (0.93 ± 0.11 vs. 0.96 ± 0.07, p < 0.001), and the degree of QFR decline was more obvious (-0.024 ± 0.090 vs. -0.008 ± 0.070, p = 0.023) in the diabetic group. Additionally, diabetes was independently associated with functional restenosis (OR: 2.164; 95% CI: 1.210-3.870, p = 0.009) and target vessel failure (TVF) (OR: 2.654; 95% CI: 1.405-5.012, p = 0.003). CONCLUSION As evaluated by the QFR, patients with diabetes received less coronary physiological benefit from PCI, which was consistent with their clinical outcomes.