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Combination of anti‐CD25 antibody and poly I:C treatment in pregnant NOD mice may be used as ‘pregnancy‐related’ type 1 diabetes model

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Some women develop type 1 diabetes during pregnancy or immediately after delivery. However, the underlying pathophysiology remains largely unknown, probably because of the lack of a suitable animal model. In this… Click to show full abstract

Some women develop type 1 diabetes during pregnancy or immediately after delivery. However, the underlying pathophysiology remains largely unknown, probably because of the lack of a suitable animal model. In this study, we administered pregnant NOD mice with an anti‐CD25 antibody to reduce regulatory T cells along with poly I:C and examined the onset of diabetes.

Keywords: pregnant nod; nod mice; type diabetes; cd25 antibody; anti cd25

Journal Title: Journal of Diabetes Investigation
Year Published: 2022

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