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Formation of the PEN2‐ATP6AP1 complex induced by the binding of metformin to PEN2 results in the inhibition of v‐ATPase activity and in the recruitment of AXIN/LKB1 to lysosomes, which in… Click to show full abstract
Formation of the PEN2‐ATP6AP1 complex induced by the binding of metformin to PEN2 results in the inhibition of v‐ATPase activity and in the recruitment of AXIN/LKB1 to lysosomes, which in turn results in the phosphorylation and activation of AMPK.
Keywords:
mechanism metformin;
action mediated;
mediated lysosomal;
new mechanism;
lysosomal presenilin;
metformin action
Journal Title: Journal of Diabetes Investigation
Year Published: 2022
Link to full text (if available)
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Journal Title: Journal of Diabetes Investigation
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!