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Selenoprotein P (SeP; encoded by SEPP1 in humans) is a hepatokine that causes impaired insulin secretion and insulin resistance. Metformin downregulates SELENOP promoter activity through an adenosine monophosphate‐activated kinase–forkhead box protein O3a… Click to show full abstract
Selenoprotein P (SeP; encoded by SEPP1 in humans) is a hepatokine that causes impaired insulin secretion and insulin resistance. Metformin downregulates SELENOP promoter activity through an adenosine monophosphate‐activated kinase–forkhead box protein O3a pathway in hepatocytes. This study aimed to test our hypothesis that circulating SeP levels are associated with the glucose‐lowering effect of metformin in humans.
Keywords:
circulating selenoprotein;
predict glucose;
selenoprotein;
glucose lowering;
levels predict;
selenoprotein levels
Journal Title: Journal of Diabetes Investigation
Year Published: 2022
Link to full text (if available)
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Journal Title: Journal of Diabetes Investigation
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!