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Glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 secretion in humans: Characteristics and regulation

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Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are important incretin hormones. They are released from the gut after meal ingestion and potentiate glucose‐stimulated insulin secretion. Their release after meal… Click to show full abstract

Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are important incretin hormones. They are released from the gut after meal ingestion and potentiate glucose‐stimulated insulin secretion. Their release after meal ingestion and oral glucose are well established and have been characterized previously. During recent years, knowledge of other regulatory aspects that potentially may affect GIP and GLP‐1 secretion after meal ingestion have also begun to emerge. Here, the results of human studies on these novel aspects of meal‐ and nutrient‐stimulated incretin hormone secretion are reviewed.

Keywords: glucose dependent; insulinotropic polypeptide; glucagon like; secretion; dependent insulinotropic; like peptide

Journal Title: Journal of Diabetes Investigation
Year Published: 2022

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