Malignant Melanoma (MM) is characterized by a growing incidence and a high malignant potential. Besides well‐defined prognostic factors such as tumour thickness and ulceration, the Mitotic Rate (MR) was included… Click to show full abstract
Malignant Melanoma (MM) is characterized by a growing incidence and a high malignant potential. Besides well‐defined prognostic factors such as tumour thickness and ulceration, the Mitotic Rate (MR) was included in the AJCC recommendations for diagnosis and treatment of MM. In daily routine, the identification of a single mitosis can be difficult on haematoxylin and eosin slides alone. Several studies showed a big inter‐ and intra‐individual variability in detecting the MR in MM even by very experienced investigators, thus raising the question for a computer‐assisted method.
               
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