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Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP‐2, MMP‐9, MMP‐12) and their inhibitor TIMP‐2

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The project was scheduled as a case–control study to investigate the correlation between MMP‐2 (rs243864), MMP‐9 (3918242), MMP‐12 (rs7123600) and TIMP‐2 (rs8176329) polymorphisms and chronic venous disease (CVD) risk. The… Click to show full abstract

The project was scheduled as a case–control study to investigate the correlation between MMP‐2 (rs243864), MMP‐9 (3918242), MMP‐12 (rs7123600) and TIMP‐2 (rs8176329) polymorphisms and chronic venous disease (CVD) risk. The genotype and phenotype research envisages the testing of possible associations between MMP and TIMP‐2 genotypes and phenotypes of CVD.

Keywords: venous insufficiency; mmp; chronic venous; predisposition chronic; mmp mmp; genetic predisposition

Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2017

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