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Loss‐of‐function mutations in filaggrin gene and malignant melanoma: a case–control study

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Loss‐of‐function mutations in filaggrin gene (FLG) have been suggested to increase the susceptibility of skin malignancies due to reduced levels of epidermal filaggrin and its degradation products, urocanic acid, which… Click to show full abstract

Loss‐of‐function mutations in filaggrin gene (FLG) have been suggested to increase the susceptibility of skin malignancies due to reduced levels of epidermal filaggrin and its degradation products, urocanic acid, which may be protective against ultraviolet irradiation.

Keywords: loss function; mutations filaggrin; function mutations; filaggrin gene

Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2018

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