"Use of reflectance confocal microscopy to evaluate 5‐fluorouracil 0.5%/salicylic acid 10% in the field‐directed treatment of subclinical lesions of actinic keratosis: subanalysis of a Phase III, randomized, double‐blind, vehicle‐controlled trial"

Use of reflectance confocal microscopy to evaluate 5‐fluorouracil 0.5%/salicylic acid 10% in the field‐directed treatment of subclinical lesions of actinic keratosis: subanalysis of a Phase III, randomized, double‐blind, vehicle‐controlled trial

Actinic keratosis (AK) is a common skin disorder that can progress to invasive squamous‐cell carcinoma. AK can present as clinical (visible) or subclinical (invisible) lesions within areas of chronic sun damage. The importance of treating subclinical AK is gaining support. We present a subanalysis of a previously published Phase III, double‐blind, vehicle‐controlled study (NCT02289768), to assess 5‐fluorouracil (5‐FU) 0.5%/salicylic acid 10% treatment of subclinical AK lesions, based on reflectance confocal microscopy (RCM).

Keywords: blind vehicle; microscopy; phase iii; vehicle controlled; double blind; actinic keratosis

Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2018

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