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Atopic dermatitis (AD) is a chronic, systemic disease that has a multifactorial etiology, where immune system disorders and epidermal barrier dysfunction are added to the influence of genetic and environmental… Click to show full abstract
Atopic dermatitis (AD) is a chronic, systemic disease that has a multifactorial etiology, where immune system disorders and epidermal barrier dysfunction are added to the influence of genetic and environmental factors. In AD, Th2 lymphocytes secrete several cytokines, where IL-4 / IL-13 play a key role in the proinflammatory loop, decreasing the expression of structural proteins of the epidermis, and leading to the formation of inflammatory and very pruritic lesions. Dupilumab is a fully human monoclonal antibody (mAb) targeted against the α-subunit of interleukins 4 and 13 receptors (IL-4Rα) that blocks the signaling of both IL-4 and IL-13. This article is protected by copyright. All rights reserved.
Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2019
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