LAUSR

Palmoplantar keratoderma (PPK) constitutes a heterogenous group of disorders that may be further subdivided into hereditary and acquired forms, characterized by hyperkeratosis of the palm and sole skin [1,2]. In recent years, the exponentially increasing use of next-generation sequencing technologies has led to the identification of several novel disease genes, substantially contributing to better comprehend PPK's molecular basis. PPK involvement may severely limit normal activities and lead to palmar retractions, digital amputations due to ischaemic strictures, and intense pain requiring major analgesic therapy. This article is protected by copyright. All rights reserved.