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Disseminated superficial actinic porokeratosis (DSAP) is the most common subtype of porokeratosis exhibiting an autosomal dominant mode. It is characterized by multiple small, annular, keratotic lesions that are located predominantly… Click to show full abstract
Disseminated superficial actinic porokeratosis (DSAP) is the most common subtype of porokeratosis exhibiting an autosomal dominant mode. It is characterized by multiple small, annular, keratotic lesions that are located predominantly on sun-exposed areas of the skin1,2 .Up to now, six loci have been reported to be linked to DSAP3 .Beside the mutations in the mevalonate pathway genes MVK, PMVK, MVD and FDPS1,4 , mutations in SSH1, SART3 and SLC17A9 have also been suggested to be responsible for DSAP5-7 .However, it is suspected that SSH1 is probably not causal to DSAP for it is not confirmed in other previous studies. This article is protected by copyright. All rights reserved.
Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2019
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