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Research on function and mechanisms of a novel small molecule WG449E for hypertrophic scar

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Hypertrophic scars are complications of severe wound healing characterized by excessive fibrosis associated with aberrant function of fibroblasts. However, no available drugs can be utilized to effectively treat these scars.… Click to show full abstract

Hypertrophic scars are complications of severe wound healing characterized by excessive fibrosis associated with aberrant function of fibroblasts. However, no available drugs can be utilized to effectively treat these scars. The transforming growth factor β (TGFβ) signalling pathway regulates collagen synthesis and plays an important role in scar formation.

Keywords: novel small; function mechanisms; function; scar; research function; mechanisms novel

Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2019

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