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An adult case of X‐linked chronic granulomatous disease with skin ulcer on the nose and internal canthus

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Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disease in which phagocytes are unable to produce reactive oxygen species (ROS) due to an impaired NADPH oxidase complex. Beginning in… Click to show full abstract

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disease in which phagocytes are unable to produce reactive oxygen species (ROS) due to an impaired NADPH oxidase complex. Beginning in infancy, patients suffer recurrent infections, especially catalase-positive bacteria and fungi, and the formation of tissue granulomas due to dysregulated inflammation.1 Antimicrobial prophylaxis has enabled CGD patients to survive into adulthood.

Keywords: granulomatous disease; chronic granulomatous; linked chronic; case linked; disease; adult case

Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2020

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