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Dupilumab‐induced serum sickness‐like reaction: an unusual adverse effect in a patient with atopic eczema

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Dupilumab is a fully humanized Immunoglobulin-(Ig)-G4 antibody against the interleukin (IL)-4α subunit of the IL-4- and the IL-13-receptor.1 In patients with atopic eczema (AE), most frequent adverse reactions include injection… Click to show full abstract

Dupilumab is a fully humanized Immunoglobulin-(Ig)-G4 antibody against the interleukin (IL)-4α subunit of the IL-4- and the IL-13-receptor.1 In patients with atopic eczema (AE), most frequent adverse reactions include injection site reactions and conjunctivitis/blepharitis.1,2 Recently, a case with suspicion of an IgE-mediated hypersensitivity was reported.3 We herein report upon a patient who developed serum sickness like reaction (SSLR) under therapy with dupilumab.

Keywords: like reaction; serum sickness; atopic eczema; sickness like; dupilumab

Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2020

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