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Six cases of chloracne in Italy: the success of combined therapy

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Chloracne is a rare disfiguring disease related to dioxin exposure. A paucity of literature exists on the clinical manifestations of this disease and how best to treat it1 . Dioxin… Click to show full abstract

Chloracne is a rare disfiguring disease related to dioxin exposure. A paucity of literature exists on the clinical manifestations of this disease and how best to treat it1 . Dioxin acts in humans through an intracellular receptor, the aryl hydrocarbon receptor (AhR), which causes gene encoding of the enzyme cytochrome P450 1A1(CYP1A1). The expression of CYP1A1 in human skin is a diagnostic biomarker in acne-like lesions known as chloracne or "metabolizing acquired dioxin-induced skin hamartomas'(MADISH)2,3 .

Keywords: six cases; cases chloracne; combined therapy; chloracne italy; italy success; success combined

Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2020

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