The mortality rate of COVID-19 has been observed to be higher in males than in females internationally.(1) In humans, the only known promoter of the TMPRSS2 gene is an androgen… Click to show full abstract
The mortality rate of COVID-19 has been observed to be higher in males than in females internationally.(1) In humans, the only known promoter of the TMPRSS2 gene is an androgen response element; (2, 3) therefore, androgens could potentially explain the sexual dimorphism observed in COVID-19 disease burden.(4).
               
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