Photo from wikipedia
Upper dermal mast cells are markers of chronic photoexposure and they are more prominent in melasma than in unaffected adjacent skin.1 As mast cells degranulate under stimulation (e.g., heat, UV… Click to show full abstract
Upper dermal mast cells are markers of chronic photoexposure and they are more prominent in melasma than in unaffected adjacent skin.1 As mast cells degranulate under stimulation (e.g., heat, UV exposure), and several treatments for melasma, such as oral tranexamic acid, topical nicotinamide, and topical corticosteroids reduce them, such cells are thought to play a key role in melasma pathogenesis.2,3 To date, there are no studies exploring the stabilization of mast cells and H2 blockade as a potential therapeutic strategy in melasma.
Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!