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Secretory leukocyte protease inhibitor regulates nerve reflex‐mediated skin barrier function in psoriasis

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Secretory leukocyte protease inhibitor (SLPI), a ~12 kDa protein is an important regulator of innate and adaptive immunity and a component of tissue regenerative programmes. SLPI expression is markedly elevated in… Click to show full abstract

Secretory leukocyte protease inhibitor (SLPI), a ~12 kDa protein is an important regulator of innate and adaptive immunity and a component of tissue regenerative programmes. SLPI expression is markedly elevated in chronically inflamed skin, including that of individuals suffering from psoriasis. However, the role of SLPI in these diseases remains elusive.

Keywords: protease inhibitor; leukocyte protease; secretory leukocyte

Journal Title: Journal of the European Academy of Dermatology and Venereology
Year Published: 2022

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