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Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor‐β1/Smads pathway through shikonin

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Liver fibrosis is a worldwide clinical challenge during the progression of chronic liver disease to liver cirrhosis. Shikonin is extracted from the root of Lithospermum erythrorhizon with antioxidant, anti‐inflammatory, anticancer,… Click to show full abstract

Liver fibrosis is a worldwide clinical challenge during the progression of chronic liver disease to liver cirrhosis. Shikonin is extracted from the root of Lithospermum erythrorhizon with antioxidant, anti‐inflammatory, anticancer, and wound‐healing properties. The study aims to investigate the protective effect of shikonin on liver fibrosis and its underlying mechanism.

Keywords: alleviation hepatic; fibrosis; via inhibition; autophagy via; hepatic fibrosis; fibrosis autophagy

Journal Title: Journal of Gastroenterology and Hepatology
Year Published: 2019

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