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Improved prediction of mortality by combinations of inflammatory markers and standard clinical scores in patients with acute‐on‐chronic liver failure and acute decompensation

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Acute‐on‐chronic liver failure (ACLF) is a sinister prognosis, and there is a need for accurate biomarkers and scoring systems to better characterize ACLF patients and predict prognosis. Systemic inflammation and… Click to show full abstract

Acute‐on‐chronic liver failure (ACLF) is a sinister prognosis, and there is a need for accurate biomarkers and scoring systems to better characterize ACLF patients and predict prognosis. Systemic inflammation and renal failure are hallmarks in ACLF disease development and progression. We hypothesized that the combination of specific inflammatory markers in combination with clinical scores are better predictors of survival than the originally developed CLIF‐C acute decompensation (AD) and CLIF‐C ACLF scores.

Keywords: liver failure; clinical scores; chronic liver; inflammatory markers; failure; acute chronic

Journal Title: Journal of Gastroenterology and Hepatology
Year Published: 2020

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