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Nfatc1+ colonic stem cells contribute to regeneration upon colitis

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Colonic stem cells play important roles in both normal epithelial turnover and injury repair. Lgr5+ colonic stem cells are highly susceptible to DSS‐induced damage. However, it is still unclear how… Click to show full abstract

Colonic stem cells play important roles in both normal epithelial turnover and injury repair. Lgr5+ colonic stem cells are highly susceptible to DSS‐induced damage. However, it is still unclear how colonic stem cells regenerate injured epithelium during colitis. Here, we explored the functions of a new population of NFATc1+ colonic stem cells in experimental colitis.

Keywords: nfatc1 colonic; colitis; cells contribute; stem cells; colonic stem

Journal Title: Journal of Gastroenterology and Hepatology
Year Published: 2022

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