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miR‐144‐3p/miR‐451a promotes lymphovascular invasion through repression of PTEN/p19 in rectal neuroendocrine tumors

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Although rectal neuroendocrine tumor (NET‐G1) have potential metastatic capability, even among small tumors, no predictive biomarker for invasion and metastasis has been reported. We analyzed microRNA (miRNA) expression profiles in… Click to show full abstract

Although rectal neuroendocrine tumor (NET‐G1) have potential metastatic capability, even among small tumors, no predictive biomarker for invasion and metastasis has been reported. We analyzed microRNA (miRNA) expression profiles in rectal NET‐G1 tissues with and without lymphovascular invasion (LVI). Moreover, we then investigated their target genes to clarify the mechanism of invasion/metastasis in NET‐G1.

Keywords: 144 mir; invasion; rectal neuroendocrine; mir 144; lymphovascular invasion; mir 451a

Journal Title: Journal of Gastroenterology and Hepatology
Year Published: 2022

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