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Validation of magnetic resonance elastography plus fibrosis‐4 for significant fibrosis in nonalcoholic fatty liver disease

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MEFIB (the combination of magnetic resonance elastography [MRE] ≥ 3.3 kPa and fibrosis‐4 (FIB‐4) ≥ 1.6) is useful for detecting patients with significant fibrosis (fibrosis stage ≥ 2) having nonalcoholic… Click to show full abstract

MEFIB (the combination of magnetic resonance elastography [MRE] ≥ 3.3 kPa and fibrosis‐4 (FIB‐4) ≥ 1.6) is useful for detecting patients with significant fibrosis (fibrosis stage ≥ 2) having nonalcoholic fatty liver disease (NAFLD). However, age‐dependent thresholds of FIB‐4 have been proposed, and it remains unclear whether MEFIB could be applied with the same FIB‐4 threshold in a different cohort. Therefore, in this study, we examined the best threshold of FIB‐4 and validated the utility of MEFIB.

Keywords: magnetic resonance; nonalcoholic fatty; fatty liver; resonance elastography; significant fibrosis; fibrosis

Journal Title: Journal of Gastroenterology and Hepatology
Year Published: 2022

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