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Dose intensification strategy influences infliximab pharmacokinetics but not clinical response after the same number of doses

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The optimal infliximab dose intensification strategy to address secondary loss of response (LOR) remains unclear. This study aimed to compare clinical and pharmacokinetic outcomes following (i) upfront infliximab re‐induction with… Click to show full abstract

The optimal infliximab dose intensification strategy to address secondary loss of response (LOR) remains unclear. This study aimed to compare clinical and pharmacokinetic outcomes following (i) upfront infliximab re‐induction with (ii) ongoing 6‐weekly dose interval shortening (DIS), after the same number of doses.

Keywords: number doses; intensification strategy; response; dose intensification

Journal Title: Journal of Gastroenterology and Hepatology
Year Published: 2023

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