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A metagenomic study identifies a Prevotella copri enriched microbial profile associated with non‐alcoholic steatohepatitis in subjects with obesity

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Non‐alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease. Increasing evidence indicates that the gut microbiota can play an important role in the pathophysiology of NAFLD.… Click to show full abstract

Non‐alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease. Increasing evidence indicates that the gut microbiota can play an important role in the pathophysiology of NAFLD. Recently, several studies have tested the predictive value of gut microbiome profiles in NAFLD progression; however, comparisons of microbial signatures in NAFLD or non‐alcoholic steatohepatitis (NASH) have produced discrepant results, possibly due to ethnic and environmental factors. Thus, we aimed to characterize the gut metagenome composition of patients with fatty liver disease.

Keywords: non alcoholic; alcoholic steatohepatitis; metagenomic study; study identifies; liver disease

Journal Title: Journal of Gastroenterology and Hepatology
Year Published: 2023

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