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Skeletal muscle atrophy is exacerbated by steatotic and fibrotic liver‐derived TNF‐α in senescence‐accelerated mice

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Although liver diseases, including non‐alcoholic steatohepatitis, are associated with skeletal muscle atrophy, the mechanism behind their association has not been fully elucidated. In this study, the effects of aging and… Click to show full abstract

Although liver diseases, including non‐alcoholic steatohepatitis, are associated with skeletal muscle atrophy, the mechanism behind their association has not been fully elucidated. In this study, the effects of aging and non‐alcoholic steatohepatitis on the skeletal muscle, and the interaction between the liver and muscle were investigated using a diet‐induced non‐alcoholic steatohepatitis model in senescence‐accelerated mice.

Keywords: liver; accelerated mice; senescence accelerated; muscle; muscle atrophy; skeletal muscle

Journal Title: Journal of Gastroenterology and Hepatology
Year Published: 2022

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