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BCL6 BTB‐specific inhibition via FX1 treatment reduces Tfh cells and reverses lymphoid follicle hyperplasia in Indian rhesus macaque (Macaca mulatta)

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The BTB domain of B‐cell lymphoma 6 (BCL6) protein was identified as a therapeutic target for B‐cell lymphoma. This study compared the pharmacokinetics (PK) of the BCL6 BTB inhibitor (FX1)… Click to show full abstract

The BTB domain of B‐cell lymphoma 6 (BCL6) protein was identified as a therapeutic target for B‐cell lymphoma. This study compared the pharmacokinetics (PK) of the BCL6 BTB inhibitor (FX1) between mice and macaques, as well as evaluating its lymphoid suppressive effect in uninfected macaques with lymphoid hyperplasia.

Keywords: btb; specific inhibition; bcl6 btb; btb specific; inhibition via; fx1

Journal Title: Journal of Medical Primatology
Year Published: 2019

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