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Through the accumulation of adaptive mutations, HIV‐2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross‐species transmission event. Various… Click to show full abstract
Through the accumulation of adaptive mutations, HIV‐2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross‐species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4+ T‐cell decline as the virus was passaged in humanized mice.
Keywords:
towards hiv;
sivsm humanized;
evolution sivsm;
humanized mice;
mice towards;
mice
Journal Title: Journal of Medical Primatology
Year Published: 2020
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Journal Title: Journal of Medical Primatology
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!