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Nodes of Ranvier in skin biopsies of patients with diabetes mellitus

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Paranodal demyelination has been discussed as a potential mechanism of nerve fiber damage in diabetic neuropathy (DNP). Studies on human tissue are limited, as nerve biopsies are invasive and only… Click to show full abstract

Paranodal demyelination has been discussed as a potential mechanism of nerve fiber damage in diabetic neuropathy (DNP). Studies on human tissue are limited, as nerve biopsies are invasive and only rarely performed in patients with confirmed DNP. Skin biopsy has recently been suggested as a tool to analyze paranodal and nodal changes of myelinated fibers.

Keywords: patients diabetes; nodes ranvier; biopsies patients; skin biopsies; diabetes mellitus; ranvier skin

Journal Title: Journal of the Peripheral Nervous System
Year Published: 2017

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