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Systemic sclerosis (SSc) fibroblasts show resistance apoptosis mechanisms, which enhances the fibrosis stage of the disease. Impaired function of p53 upregulated modulator of apoptosis (PUMA) has been related to deficits… Click to show full abstract
Systemic sclerosis (SSc) fibroblasts show resistance apoptosis mechanisms, which enhances the fibrosis stage of the disease. Impaired function of p53 upregulated modulator of apoptosis (PUMA) has been related to deficits in p53‐dependant apoptosis pathway. This study aimed to evaluate the transcriptional levels of p53 and PUMA mRNAs in fibroblasts from SSc patients and compare it with healthy individuals.
Keywords:
puma fibroblasts;
expressions p53;
p53 puma;
fibroblasts systemic;
systemic sclerosis
Journal Title: Journal of Cosmetic Dermatology
Year Published: 2018
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Journal Title: Journal of Cosmetic Dermatology
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!