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CRH receptor antagonists from Pulsatilla chinensis prevent CRH‐induced premature catagen transition in human hair follicles

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There is a growing interest in the relationship among stress hormones, neuroendocrine signaling, and skin diseases, including hair loss. Previous reports showed that stress hormones inhibit human hair growth and… Click to show full abstract

There is a growing interest in the relationship among stress hormones, neuroendocrine signaling, and skin diseases, including hair loss. Previous reports showed that stress hormones inhibit human hair growth and induce early catagen transition. Moreover, a CRH receptor antagonist reversed CRH‐induced alopecia in a mouse model, suggesting that antagonization of the CRH receptor is a key clinical strategy to treat stress‐induced hair loss.

Keywords: catagen transition; crh; crh receptor; human hair

Journal Title: Journal of Cosmetic Dermatology
Year Published: 2020

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