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Warts are viral cutaneous infections caused by human papilloma virus (HPV), presented by verrucous growth over the skin surface. The immune response is considered to play a crucial role in… Click to show full abstract
Warts are viral cutaneous infections caused by human papilloma virus (HPV), presented by verrucous growth over the skin surface. The immune response is considered to play a crucial role in HPV clearance. It depends on intact cellular immunity including natural killer (NK) cell and cytotoxic T cells. It has been clarified that T‐helper (Th) 1 cytokines (interleukin (IL)‐2, interferon‐γ, and tumor necrosis factor‐a) and IL‐17 are involved in HPV clearance. IL‐22 is one of IL‐10 family of cytokines produced by NK cells, Th1, Th17, and Th22 cells. In the skin, IL‐22 reduces keratinocyte cornification and enhances keratinocyte production of antimicrobial peptides. IL‐22 overexpression has been demonstrated in various viral infections and skin inflammatory disorders.
Journal Title: Journal of Cosmetic Dermatology
Year Published: 2020
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