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TIMP2 genetic variation rs4789932 may associate with an increased risk of developing acne scarring based on a case‐control study of Chinese Han population

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Acne vulgaris is a common chronic inflammatory cutaneous disorder that has a higher prevalence in adolescents and young adults. Previous studies have indicated that both genetic and environmental factors contribute… Click to show full abstract

Acne vulgaris is a common chronic inflammatory cutaneous disorder that has a higher prevalence in adolescents and young adults. Previous studies have indicated that both genetic and environmental factors contribute to its risk. The protein encoded by the TIMP2 gene is a natural inhibitor of matrix metalloproteinases (MMPs). Changes in TIMP2 expression are speculated to disrupt the TIMP/MMP balance and result in acne scarring.

Keywords: genetic variation; rs4789932 may; variation rs4789932; acne scarring; risk; timp2 genetic

Journal Title: Journal of Cosmetic Dermatology
Year Published: 2022

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