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Role of HIF‐1α in pathogenic mechanisms of keloids

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Keloids are defined as overrepairing products that develop after skin lesions. Keloids are characterized by the proliferation of fibroblasts and the overaccumulation of extracellular matrix components (mainly collagen), leading to… Click to show full abstract

Keloids are defined as overrepairing products that develop after skin lesions. Keloids are characterized by the proliferation of fibroblasts and the overaccumulation of extracellular matrix components (mainly collagen), leading to a locally hypoxic microenvironment. Hence, this article was aimed to review hypoxia in pathogenesis of keloids.

Keywords: hif pathogenic; dermatology; mechanisms keloids; role hif; pathogenic mechanisms

Journal Title: Journal of Cosmetic Dermatology
Year Published: 2023

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