LAUSR

“ Comparison between surgery and fibrinolytic therapy in prosthetic valve thrombosis: A systematic review and meta ‐ analysis. ” 1 for their study comparing the efficacy and safety of surgery and fibrinolytic therapy (FT) in prosthetic valve thrombosis (PVT). We would like to emphasize some points in light of the current evidence. meta ‐ analysis ‐ dose, slow infusion of tissue plasminogen several trials safety and efficacy of FT regimens low ‐ dose and slow infusion of t PA. 2 – 5 In TROIA trial, a low ‐ dose slow infusion h) t and a safer regimen in the management of PVT as compared with high ‐ dose and fast ‐ infusion regimens. 2 Sadeghipour et al. 5 regimen, safety profile, reference strategy treatment PVT. dose FT mortality and in NYHA class I – IV patients obstructive PVT FT in patients obstructive PVT