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To investigate the protective effect of small peptides from Periplaneta americana (SPPA) on cyclophosphamide (CP)‐induced premature ovarian failure (POF) in mice. Silent mating type information regulation 2 homolog 1 (SIRT1)… Click to show full abstract
To investigate the protective effect of small peptides from Periplaneta americana (SPPA) on cyclophosphamide (CP)‐induced premature ovarian failure (POF) in mice. Silent mating type information regulation 2 homolog 1 (SIRT1) /tumor‐associated protein 53 (p53) signaling pathway plays an important role in delaying POF. Hematopoietic progenitor cell antigen (CD34) reflects ovarian aging from the side. However, whether SPPA inhibits POF in mice by influencing the SIRT1/p53 pathway and CD34 expression remains to be studied.
Journal Title: Journal of Obstetrics and Gynaecology Research
Year Published: 2021
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