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Intestinal alkaline phosphatase at the crossroad of intestinal health and disease – a putative role in type 1 diabetes

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Patients with type 1 diabetes have shown an increase in circulating cytokines, altered lipoprotein metabolism and signs of vascular dysfunction in response to high‐fat meals. Intestinal alkaline phosphatase (IAP) regulates… Click to show full abstract

Patients with type 1 diabetes have shown an increase in circulating cytokines, altered lipoprotein metabolism and signs of vascular dysfunction in response to high‐fat meals. Intestinal alkaline phosphatase (IAP) regulates lipid transport and inflammatory responses in the gastrointestinal tract. We therefore hypothesized that changes in IAP activity could have profound effects on gut metabolic homeostasis in patients with type 1 diabetes.

Keywords: crossroad intestinal; phosphatase crossroad; type diabetes; intestinal alkaline; alkaline phosphatase

Journal Title: Journal of Internal Medicine
Year Published: 2017

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